The biology of a shape-shifting virus
The genetic shield of natural resistance
Molecular scissors and cellular factories
The hiding spots and the latent reservoir
007skaty Engineered Antibodies for HIV
Three target sites are locked in one (locked in one) / To stop the virus on the run (on the run)
007skaty Resting T-cells look completely normal to the immune system, protecting inactive HIV from drugs until treatment stops.
007skaty Latency-reversing drugs expose hidden HIV reservoirs for targeted immune system attacks.
007skaty Decode viral DNA sequences to discover how scientists silence dormant HIV forever.
Latent lifespan: Some latently infected memory T-cells can survive in the human body for over 70 years, making lifetime treatment necessary without a cure.
A population of host cells in the body that contain a dormant pathogen and do not actively replicate. Robert Siliciano's Johns Hopkins laboratory demonstrated the existence of this viral pool in 1995.
Why can standard antiretroviral therapy (ART) not eliminate the latent HIV reservoir?
In which specific type of immune cell does the primary latent reservoir of HIV reside?
What is the primary goal of the 'shock' phase in the 'shock and kill' cure strategy?
Which viral protein, essential for enhancing HIV transcription, is a primary target of 'block and lock' drugs?
What makes 'broadly neutralizing antibodies' (bnAbs) different from standard antibodies produced against HIV?