Decoding the tumor genetic blueprint
Mapping the tumor microenvironment
High tech tools of reverse engineering
Designing the targeted counter attack
007skaty Next-generation sequencing technology maps the genetic blueprints of cancer cells
007skaty Defective DNA Repair
When DNA repair is broken (broken!) / we block the backup PARP to break the cell (oh yeah!)
007skaty Isolating BRCA1 in 1990 and BRCA2 in 1995 revealed how mutations in these DNA-repairing genes raise breast cancer risk up to 80%.
007skaty Losing p53 tumor suppressors removes the brakes that stop damaged cells from dividing.
007skaty Match gene sequences to discover how scientists reverse engineer breast cancer cures.
BRCA gene name: The term BRCA stands simply for BReast CAncer, representing the first genes linked directly to inherited breast cancer risk.
The complete set of genetic material or DNA present in an organism. The Vera Bradley Foundation Center sequences this DNA to target mutations in aggressive breast tumors.
What is the primary biological function of the healthy BRCA1 and BRCA2 genes in human cells?
Which tumor suppressor gene is often called the guardian of the genome because it stops cell division to repair damaged DNA?
What percentage of breast cancers are characterized by an overabundance or amplification of the HER2 oncogene?
In what year did scientists officially complete the first draft of mapping the entire human genome?
How does next-generation sequencing assist oncologists in treating breast cancer patients?
Approximately how many DNA lesions or damage events does a single human cell experience every day?