Yellow Light Brake: Controlling Brain Cells
Chapter 1

The pond scum superpower

Chapter 2

Engineering the neural light switch

Chapter 3

The rainbow dashboard of the brain

Chapter 4

Healing minds and restoring sight

YOUR GOAL

Master of Shining a light on the brain

Ch 3 · The rainbow dashboard of the brain
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007skaty Researchers map the brain regions that control basic emotional drives.

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007skaty Optogenetics

Flash the blue light to turn a neuron on, hit the yellow laser to shut it down.

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Our deepest memories and emotions are physical states that can be switched on and off.

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007skaty The memory maker experiment analyzed how brain cells physically store memories.

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Mapping the emotional highway

007skaty Controlling specific neurons helps researchers map the brain regions responsible for deep-seated drives like appetite, aggression, and sleep

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The yellow light brake

007skaty Yellow light beams push negative chloride ions through halorhodopsin channels in a neuron.

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Rainbow Brain Buttons
BETA

007skaty Tap the colored brain buttons to discover how scientists control brain cells with light.

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Fun Fact

Salt-marsh silencers: The protein used to turn neurons off with yellow light, halorhodopsin, comes from ancient microbes that live in ultra-salty desert lakes.

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Glossary
optogenetics (noun)
A biological technique that uses light to control the activity of genetically modified neurons. In 2005, Karl Deisseroth first successfully used blue light to activate mammalian neurons engineered with algal proteins.

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Gossip

If you could switch off one feeling, what would it be?

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Quiz

What specific type of ion rushes into the cell when yellow light activates halorhodopsin?

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Quiz

In 2012, which Nobel laureate collaborated with Karl Deisseroth to switch fear memories on and off in mice?

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Quiz

Which light-sensitive protein is used as a 'brake' to turn neurons off when exposed to yellow light?

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Quiz

Which color of light is specifically used to activate channelrhodopsin-2 and turn neurons on?

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Quiz

In 2007, scientists used optogenetics to control which bodily state by targeting hypocretin-producing neurons?

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Quiz

From what kind of organisms did scientists harvest the yellow-light-sensitive halorhodopsin protein?

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Quiz

Beyond the brain, optogenetics has been used to study and regulate which natural 24-hour cycle in living organisms?

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Quiz

In early optogenetic experiments, illuminating a specific motor cortex region allowed scientists to control which part of a mouse?

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