
The secret hormone factory
The defense against sarcopenia
The ultimate sugar sponge
Muscles talking to the brain
YOUR GOAL
Master of The body's secret longevity engine
doctorx Skeletal Muscle
Active muscle, active muscle, Releasing myokines when we hustle.
doctorx Scientists study how exercise sends chemical messages throughout the human body.

doctorx Bente Klarlund Pedersen and Mark Febbraio established skeletal muscle as a secretory organ in Nature Reviews Endocrinology.

doctorx Marathon runners helped discover myokines by showing a hundredfold increase in interleukin-6.

doctorx Match exercises to muscles to discover how strength training supports your healthspan as you age.
Muscle mass: Skeletal muscle is the single largest organ system in the human body, accounting for roughly 40% of an average person's total body weight.
A signaling protein synthesized and released by muscle cells. In 2000, researcher Bente Pedersen discovered that contracting muscles release these proteins to signal other organs.
Which Danish researcher pioneered the concept of skeletal muscle acting as an endocrine organ in the early 2000s?
In what medical journal did researchers formally propose the modern framing of skeletal muscle as an endocrine organ in 2012?
How did researchers in Denmark prove that interleukin-6 was produced specifically by contracting muscle fibers?
During a 1999 study on marathon runners, which signaling protein was found to increase 100-fold in the blood after the race?
According to a 2020 scientific synthesis in Endocrine Reviews, approximately how many unique myokines are estimated to be produced by human muscle?
A 2019 clinical trial in Cell Metabolism showed that blocking interleukin-6 (IL-6) signaling had what physical effect during exercise?
What is the name of the tiny, fluid-filled cellular bubbles that package and transport exerkines through the bloodstream to other tissues?