In what year did researchers first successfully activate mammalian
Chapter 1

The pond scum superpower

Chapter 2

Engineering the neural light switch

Chapter 3

The rainbow dashboard of the brain

Chapter 4

Healing minds and restoring sight

YOUR GOAL

Master of Shining a light on the brain

Ch 2 · Engineering the neural light switch
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007skaty The millisecond optical switch controls brain cells with light.

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007skaty Optogenetics

With algal proteins engineered inside the cell, We trigger neurons with a blue light pulse as well.

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To influence a system without disrupting it, we must make it sensitive to new signals.

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007skaty Francis Crick sought a precise method to stimulate individual brain cells.

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The millisecond optical switch

007skaty Karl Deisseroth and Ed Boyden used algal channelrhodopsin to make cultured rat neurons fire natural electrical signals under

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The viral delivery truck

007skaty A futuristic viral delivery truck transports light-sensitive DNA codes to targeted brain cells

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Brain Beam Switch
BETA

007skaty Switch the light beams to learn how scientists control brain cells.

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Fun Fact

Flash of genius: The very first successful experiment to control a mammalian neuron with light happened in the middle of the night on July 1, 2004.

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Glossary
optogenetics (noun)
A method of using light to control genetically modified, light-sensitive cells in living tissue. In 2005, Stanford researcher Karl Deisseroth successfully engineered mammalian neurons to respond to pulses of blue light.

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Gossip

Should scientists be allowed to edit human brain genes?

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Quiz

Which neuroengineer worked alongside Karl Deisseroth in 2005 to pioneer this genetic light-control technology?

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007skaty Scientists connect flexible fiber-optic cables to the brains of living mice

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Quiz

In what year did researchers first successfully activate mammalian brain cells in a dish using channelrhodopsin?

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Quiz

How do scientists deliver light to targeted cells deep inside the brains of living, active laboratory mice?

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Quiz

How do modern scientists deliver the light-sensitive algal gene into specific mammalian brain cells?

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Quiz

In what year was the term 'optogenetics' officially coined to describe this combination of optics and genetics?

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Quiz

On what specific date did Karl Deisseroth first observe a mammalian neuron firing in response to light in his laboratory?

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Quiz

Which Nobel laureate first suggested using light to control specific brain cells in 1979?

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Quiz

Why is 'millisecond precision' so important when controlling brain cells with optogenetics?

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