Bark That Cured Malaria: Reverse Engineering Medicine
Chapter 1

Decoding ancient remedies

Chapter 2

Copying nature's chemical weapons

Chapter 3

Working backward from the disease

Chapter 4

The digital drug revolution

Ch 1 · Decoding ancient remedies
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007skaty The discovery of heart-regulating medicine from the wild foxglove plant.

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007skaty Digitalis Heart Medicine

This wild purple foxglove slows down your beat, turning plant poison to steady your heart.

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Innovation often begins by validating what has worked for generations.

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007skaty Sweet wormwood serves as a natural weapon against malaria.

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Willow bark's secret

007skaty People chewed willow bark for thousands of years before nineteenth-century scientists isolated its active chemical, salicin, to produce aspirin.

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The malaria fighting sweet wormwood

007skaty Cold water laboratory extraction isolates artemisinin from sweet wormwood to fight malaria.

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Bark to Cure
BETA

007skaty Extract active compounds from tree bark to learn how scientists reverse engineer natural cures.

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Fun Fact

Cinchona bark trade: In the 19th century, smuggling cinchona tree seeds out of South America was punishable by death to protect the quinine monopoly.

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Glossary
codex (noun)
An ancient manuscript text in book form. In the twelfth century, European scholars translated the Kitab al-Shifa codex from Arabic into Latin.

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Gossip

Which old-school remedy would you be most willing to try?

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Quiz

Which German pharmaceutical company first marketed aspirin in 1899?

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007skaty South American cinchona bark provided the first successful treatment for malaria.

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Quiz

What compound in willow bark causes stomach irritation before it is chemically modified into aspirin?

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007skaty The history of willow bark as a natural pain reliever

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Quiz

What ancient Chinese medical text from 340 AD helped Tu Youyou isolate artemisinin?

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Quiz

Why did traditional hot-water boiling fail to extract the active artemisinin compound?

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Quiz

In which mountain range does the cinchona tree natively grow?

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Quiz

What popular carbonated beverage was originally created to make bitter quinine palatable for British soldiers?

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Quiz

What is the scientific name of the foxglove plant from which digitalis is derived?

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Quiz

What symptom of digitalis toxicity did the artist Vincent van Gogh famously paint, possibly due to taking the drug?

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