What does the CAR in CAR-T cell therapy stand for?
Chapter 1

The cellular soldiers of CAR-T

Chapter 2

Phage therapy and the viral assassins

Chapter 3

Fecal transplants and ecosystem medicine

Chapter 4

Genetically engineered micro-factories

Ch 1 · The cellular soldiers of CAR-T
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007skaty The challenge of treating solid tumors with CAR-T cell therapy.

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007skaty Solid Tumor Barrier

We cannot cross, we cannot cross. The matrix locks us out.

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To defeat a hidden threat, we must train our defenses to recognize it and endure.

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007skaty Emily Whitehead survived terminal leukemia through a revolutionary new cancer treatment.

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Reprogramming the immune system

007skaty Doctors extract patient T-cells, insert a synthetic gene using a disarmed virus, and infuse these upgraded CAR-T cells to target leukemia.

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The synthetic receptor upgrade

007skaty The synthetic receptor binds specifically to CD19 proteins found on leukemia cells

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Emily's Tiny Heroes
BETA

007skaty Guide engineered immune cells to cancer targets to discover how living drugs fight disease.

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Fun Fact

CAR-T cell longevity: Some CAR-T cells survive and patrol the body for over 10 years after a single infusion.

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Glossary
t-cell (noun)
A type of white blood cell that plays a central role in the immune system. Immunologist Michel Sadelain pioneered genetically engineering these cells to target and eliminate cancer.

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Gossip

Would you support government funding for million-dollar single-dose cures?

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Quiz

Which university spearheaded the development of the first FDA-approved CAR-T therapy, Kymriah?

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007skaty Genetic engineering upgrades human immune cells with synthetic receptors.

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Quiz

What type of white blood cell is extracted and genetically modified to create CAR-T cell therapy?

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007skaty Scientists genetically engineer the human immune system to fight cancer.

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Quiz

What specific protein marker on leukemia cells does the first approved CAR-T therapy target?

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Quiz

What does the CAR in CAR-T cell therapy stand for?

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Quiz

Which arthritis drug was used to successfully treat Emily Whitehead's severe cytokine release syndrome?

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Quiz

In what year did Emily Whitehead receive her historic, life-saving CAR-T cell infusion?

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Quiz

Why are solid tumors harder for CAR-T cells to treat than blood cancers?

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Quiz

What is the term for CAR-T cells engineered to release hostile-environment-fighting chemicals?

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