The biology of a shape-shifting virus
The genetic shield of natural resistance
Molecular scissors and cellular factories
The hiding spots and the latent reservoir
007skaty Gene Editing Off-Target Safety
We target only viral DNA, yeah! (Zero human cuts, oh-oh!)
007skaty CRISPR-Cas9 uses guide RNA to find viral code and a Cas9 enzyme to snip it, letting cells repair themselves.
007skaty Investigational EBT-101 therapy uses harmless AAV9 viruses to deliver CRISPR tools into cells.
007skaty Block HIV from invading healthy cells to discover how scientists reverse engineer a cure.
Bacterial origin: Bacteria have been using the CRISPR system to remember and cut up viral invaders for millions of years before humans discovered it.
A genetic engineering tool that allows researchers to make precise, targeted changes to a genome. In 2024, Amsterdam scientists successfully used this tool to eliminate the virus from infected human cells.
From which type of organism did scientists originally adapt the CRISPR-Cas9 gene-editing technology?
What component of the CRISPR-Cas9 system acts like a GPS to guide the molecular scissors to the correct DNA sequence?
Why does the EBT-101 therapy target multiple sites on the HIV genome instead of just one?
What is the name of the CRISPR-based investigational therapy that entered human clinical trials to excise HIV DNA?
Which alternative gene-editing tool, popular before CRISPR, was first used to edit the CCR5 gene in clinical trials?
What is the primary benefit of editing a patient's own stem cells to disable CCR5, rather than using a donor?
How do researchers ensure that CRISPR therapies do not accidentally cut essential human genes?