Decoding the cellular crime scene
Tricking the viral hijackers
Hacking our own immune system
Rewriting the code of life
007skaty Magic Bullet Antibodies
We fuse a fighter cell with cancer to make a bullet that never stops aiming
007skaty Custom proteins called monoclonal antibodies mimic the body's natural immune system.
007skaty Tasuku Honjo and James P. Allison blocked the PD-L1 and PD-1 handshake, leading to drugs that unleash T-cells against tumors.
007skaty CAR T-cell therapy uses custom synthetic receptors to destroy specific tumor proteins.
007skaty Decode chaotic immune messages to discover how to prevent a deadly cytokine storm.
Living drug: Unlike normal medicines that break down and leave the body, CAR-T cells are alive and can continue patrolling the bloodstream for over a decade.
The development of a disease as affected by the host's immune system. Researchers analyze how CD8+ cytotoxic T cells can drive this destructive process during severe viral infections.
Which immune cell checkpoint protein acts as an 'off switch' that cancer cells exploit to hide from destruction?
007skaty Vaccinologists reverse engineer natural B-cell and T-cell memory to trigger long-lasting protection without patients experiencing the disease.
Who shared the 2018 Nobel Prize in Physiology or Medicine for discovering cancer therapy by inhibition of negative immune regulation?
Which type of human immune cell is harvested and genetically modified to create CAR-T therapy?
What does the 'CAR' stand for in CAR-T cell therapy, a revolutionary form of personalized cancer treatment?
Who was the first pediatric patient to receive experimental CAR-T cell therapy in 2012, becoming cancer-free as a result?
Which drug, originally designed for arthritis, did doctors use to save Emily Whitehead from a severe cytokine storm?
What makes monoclonal antibodies different from the polyclonal antibodies naturally produced by the human body during an infection?